Mitochondrial dysfunction in aging: Much progress but many unresolved questions
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Mitochondrial dysfunction in aging: Much progress but many unresolved questions
The free radical theory of aging is almost 60 years old. As mitochondria are the principle source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central role for the mitochondrion in normal mammalian aging. In recent years, however, much work has questioned the importance of mitochondrial ROS in driving aging. Conversely new evidence points to other facets of mitoch...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2015
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2015.05.022